By 2006, isotope dilution mass spectrometry ( IDMS ) became the reference method.
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In addition, unlike traditional analytical methods which rely on signal intensity, isotope dilution employs signal ratios.
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Instead of isotope dilution, a known mass of stable carrier ion is added to radionuclide sample solution.
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"' Isotope dilution analysis "'is a method of determining the quantity of chemical substances.
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Isotope dilution involves the addition of a known amount of radionuclide tracer to the sample that contains a known stable element.
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To simplify the selection of internal standard, most laboratories use an analogous stable isotope in an isotope dilution type analysis.
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In the 1930s, US biochemist David Rittenberg pioneered the use of isotope dilution in biochemistry enabling detailed studies of cell metabolism.
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ICP-MS also lends itself to quantitative determinations through isotope dilution, a single point method based on an isotopically enriched standard.
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Owing to both of these advantages, the method of isotope dilution is regarded among chemistry measurement methods of the highest metrological standing.
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Most clinical laboratories now align their creatinine measurements against a new standardized isotope dilution mass spectrometry ( IDMS ) method to measure serum creatinine.
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